Op-cbio130727 472..479
نویسندگان
چکیده
Motivation: Owing to its importance in both basic research (such as molecular evolution and protein attribute prediction) and practical application (such as timely modeling the 3D structures of proteins targeted for drug development), protein remote homology detection has attracted a great deal of interest. It is intriguing to note that the profilebased approach is promising and holds high potential in this regard. To further improve protein remote homology detection, a key step is how to find an optimal means to extract the evolutionary information
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Multiple hTAF(II)31-binding motifs in the intrinsically unfolded transcriptional activation domain of VP16.
Transcriptional activation domain (TAD) in virion protein 16 (VP16) of herpes simplex virus does not have any globular structure, yet exhibits a potent transcriptional activity. In order to probe the structural basis for the transcriptional activity of VP16 TAD, we have used NMR spectroscopy to investigate its detailed structural features. Results show that an unbound VP16 TAD is not merely "un...
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Aberrant [349]. Aborted [389]. Abortion [446, 211]. Above [692]. Abrahams [699]. Abuse [613, 678]. Accepted [350]. accident [449]. accidents [276]. Accomplice [296]. Acenes [214]. Acids [446]. Acrimony [558]. Acrobats [143]. Acronym [558]. Acts [270]. actuality [576]. actually [469]. add [544]. Addiction [651, 613, 488]. Adoring [631]. advance [645]. Advanced [683, 619]. advantage [589]. Advent...
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